In the 1990s, she endured two hip replacement operations and another near-fatal bout of pneumonia and survived surgery for a benign brain tumour in 1997.
In 2004, it was revealed that she was suffering from congestive heart failure, with symptoms including fatigue and shortness of breath, and scoliosis, which twisted her spine.
But she continued to campaign for her Aids charity, which she set up in 1991 after the death of her friend and co-star Rock Hudson.
In addition to her four children - Michael Wilding, Christopher Wilding, Maria Burton-Carson and Liza Todd-Tivey - Dame Elizabeth is survived by 10 grandchildren and four great-grandchildren.
A private family funeral will be held later this week. Instead of flowers, the family has requested that contributions be made to the Elizabeth Taylor Aids Foundation.
British actress Joan Collins, who starred alongside Dame Elizabeth in the 2001 TV film These Old Broads, called her "the last of the True Hollywood Icons".
"A great beauty, a great actress and continually fascinating to the World throughout her tumultuous life and career. She will be missed," she added.
Singer George Michael said: "She also did a great deal in the last 25 yrs [sic] to help the world deal with the HIV epidemic. I am proud to have known her if only a little."
One-time co-star Sir Michael Caine also paid tribute, remembering her as "a beautiful woman, a wonderful actress, and a great human being."
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